OTX1 videos and info

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.^[1]

Kastury K, Druck T, Huebner K, et al. (1994). "Chromosome locations of human EMX and OTX genes.". Genomics 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790.
Simeone A, Acampora D, Mallamaci A, et al. (1993). "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.". EMBO J. 12 (7): 2735–47. PMID 8101484.
Acampora D, Mazan S, Avantaggiato V, et al. (1996). "Epilepsy and brain abnormalities in mice lacking the Otx1 gene.". Nat. Genet. 14 (2): 218–22. doi:10.1038/ng1096-218. PMID 8841200.
Nagao T, Leuzinger S, Acampora D, et al. (1998). "Developmental rescue of Drosophila cephalic defects by the human Otx genes.". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3737–42. PMID 9520436.
Weimann JM, Zhang YA, Levin ME, et al. (2000). "Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets.". Neuron 24 (4): 819–31. PMID 10624946.
Francks C, Fisher SE, Olson RK, et al. (2002). "Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1.". Psychiatr. Genet. 12 (1): 35–41. PMID 11901358.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Puelles E, Annino A, Tuorto F, et al. (2004). "Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.". Development 131 (9): 2037–48. doi:10.1242/dev.01107. PMID 15105370.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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