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Y box binding protein 1
PDB rendering based on 1h95.
Available structures: 1h95
Identifiers
Symbols YBX1; BP-8; CSDA2; CSDB; DBPB; MDR-NF1; MGC104858; MGC110976; MGC117250; NSEP-1; NSEP1; YB-1; YB1
External IDs OMIM: 154030 HomoloGene: 88707
Orthologs
Human Mouse
Entrez 4904 n/a


Refseq NM_004559 (mRNA)
NP_004550 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

Y box binding protein 1, officially known as YBX1, but commonly referred to as "YB-1" by researchers, is a human protein.[1] Current research is examining its involvement in cancer, and particularly in the metastasis of cancerous cells or prevention thereof.


References

  1. ^ "Entrez Gene: YBX1 Y box binding protein 1".

Further reading

  • Kolluri R, Torrey TA, Kinniburgh AJ (1992). "A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif.". Nucleic Acids Res. 20 (1): 111–6. doi:10.1093/nar/20.1.111. PMID 1738588. 
  • Kolluri R, Kinniburgh AJ (1991). "Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein.". Nucleic Acids Res. 19 (17): 4771. doi:10.1093/nar/19.17.4771. PMID 1891370. 
  • Sakura H, Maekawa T, Imamoto F, et al. (1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.". Gene 73 (2): 499–507. PMID 2977358. 
  • Didier DK, Schiffenbauer J, Woulfe SL, et al. (1988). "Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7322–6. doi:10.1073/pnas.85.19.7322. PMID 3174636. 
  • Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain.". Eur. J. Biochem. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID 7628487. 
  • Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins.". Mol. Cell. Biol. 15 (9): 5092–9. PMID 7651426. 
  • Chen NN, Chang CF, Gallia GL, et al. (1995). "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element.". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1087–91. doi:10.1073/pnas.92.4.1087. PMID 7862639. 
  • Horwitz EM, Maloney KA, Ley TJ (1994). "A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes.". J. Biol. Chem. 269 (19): 14130–9. PMID 8188694. 
  • Kashanchi F, Duvall JF, Dittmer J, et al. (1994). "Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression.". J. Virol. 68 (1): 561–5. PMID 8254772. 
  • Makino Y, Ohga T, Toh S, et al. (1996). "Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter.". Nucleic Acids Res. 24 (10): 1873–8. doi:10.1093/nar/24.10.1873. PMID 8657568. 
  • Funke B, Zuleger B, Benavente R, et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins.". Nucleic Acids Res. 24 (19): 3821–8. doi:10.1093/nar/24.19.3821. PMID 8871564. 
  • Koike K, Uchiumi T, Ohga T, et al. (1998). "Nuclear translocation of the Y-box binding protein by ultraviolet irradiation.". FEBS Lett. 417 (3): 390–4. doi:10.1016/S0014-5793(97)01296-9. PMID 9409758. 
  • Toh S, Nakamura T, Ohga T, et al. (1998). "Genomic organization of the human Y-box protein (YB-1) gene.". Gene 206 (1): 93–7. doi:10.1016/S0378-1119(97)00570-2. PMID 9461420. 
  • Sawaya BE, Khalili K, Amini S (1998). "Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat.". J. Gen. Virol. 79 ( Pt 2): 239–46. PMID 9472608. 
  • Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH (1999). "A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription.". J. Biol. Chem. 273 (49): 32957–65. doi:10.1074/jbc.273.49.32957. PMID 9830047. 
  • Ise T, Nagatani G, Imamura T, et al. (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen.". Cancer Res. 59 (2): 342–6. PMID 9927044. 
  • Safak M, Gallia GL, Khalili K (1999). "Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells.". Mol. Cell. Biol. 19 (4): 2712–23. PMID 10082537. 
  • Kelm RJ, Cogan JG, Elder PK, et al. (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter.". J. Biol. Chem. 274 (20): 14238–45. doi:10.1074/jbc.274.20.14238. PMID 10318844. 
  • Safak M, Gallia GL, Ansari SA, Khalili K (1999). "Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen.". J. Virol. 73 (12): 10146–57. PMID 10559330. 
  • Ansari SA, Safak M, Gallia GL, et al. (1999). "Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity.". J. Gen. Virol. 80 ( Pt 10): 2629–38. PMID 10573156. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Retrieved from "http://en.wikipedia.org/wiki/Y_box_binding_protein_1"
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